All posts tagged: marijuana

With CBD, marijuana-based medicine gets its first greenlight from the FDA

In a news release today, the FDA announced its approval of a marijuana-derived drug called Epidiolex for the treatment of seizures in a subset of patients suffering from severe epilepsy. Epidiolex contains CBD, a cannabis chemical compound skyrocketing in popularity and driving what is estimated to have doubled into a $200 million market in 2018.

CBD is the common abbreviation for cannabidiol, a chemical derived from cannabis. In contrast to THC, the far more popular cannabinoid CBD does not produce strong psychoactive effects when consumed. The chemical’s use in seizure prevention is well-documented in reputable research, and now, after conducting its own trials, the FDA is on board.

As the FDA itself notes, “this is the first FDA-approved drug that contains a purified drug substance derived from marijuana.” Epidiolex, produced by GW Research Ltd., is now approved to treat the conditions known as Lennox-Gastaut syndrome and Dravet syndrome.

The FDA news signals that the DEA will likely adjust its scheduling for CBD, which is currently a Schedule I substance, denoting high potential for abuse and no medical applications.

“The FDA prepares and transmits… a medical and scientific analysis of substances subject to scheduling, like CBD, and provides recommendations to the Drug Enforcement Administration (DEA) regarding controls under the [Controlled Substances Act],” the FDA stated, indicating that it will recommend that CBD be rescheduled but the act of shifting the substance’s legality is ultimately in the DEA’s hands.

Prior to the FDA decision, a press officer for the DEA confirmed to Leafly that the FDA decision will prompt action from the DEA. “If they on June 27 announce that they’re approving Epidiolex, absolutely we’ll go into a different schedule. There’s no ifs, ands, or buts about it.”

The FDA notes that it will still “take action” against illegal CBD products making “serious, unproven medical claims.”

The medicinal acknowledgment of CBD should come as good news to marijuana startups eyeing the compound for consumer and medical consumption. Cannabis-derived CBD products are available where recreational marijuana is sold, though CBD derived from industrial hemp faces fewer regulations and is even stocked by some grocery stores.

By some measures, consumer interest appears to be moving away from traditional high-potency THC-based products and toward CBD. In February, even Bon Appétit magazine got in on the trend with a story titled “What Is CBD, and Why Is It in Everything Right Now?” Cannabis startups are likely tuned into that fact and keeping an ear to the ground for the DEA decision on what by most accounts is the next big thing in cannabis.

Read more: https://techcrunch.com

Mary JaneWith CBD, marijuana-based medicine gets its first greenlight from the FDA
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The future of weed is microdosing. This company is ahead of the game

Pax CEOBharat Vasan and the Pax Era (not to scale), which will now help you microdose.
Image: pax

It’s rare that you find a company that specifically wants to help you use its product less, especially in the marijuana space. But that’s just what vaporizer maker Pax Labs is delivering in an update to its Pax Era device and app Tuesday: the ability to inhale cannabis in truly tiny doses.

This is unusual, because the era of pot prohibition was all about more: growers with limited space competed to give you a bigger and better high, packing their strains of weed with ever greater amounts of THC (and more recently the other major active ingredient, CBD). 

In the first flush of pot legalization, this extreme potency trend continued. Edibles were enormously strong (as columnist Maureen Dowd famously discovered to her chagrin), and the fashionable thing among some stoners was “dabbing” — superheating concentrated cannabinoid oil for a fast, insanely strong high. 

But with legalization spreading rapidly across the country — just yesterday, New York state got behind it — times have changed. The frontier of middle-class consumerism has opened up. Stressed suburban moms and busy executives are the new target audience, not stoners with high tolerance levels. 

Microdosing has been a thing for some time; it’s also an increasingly popular therapeutic way to take LSD. But when it comes to marijuana, establishing what doctors call the minimal effective dose has involved experimenting with tinctures or taking tiny amounts of edibles — not necessarily something a newbie has the patience or the gumption to do. 

Enter the Pax Era. Launched in late 2016, this $30 flash drive-sized vape uses concentrate-filled “pods” made by third parties (more than 250 kinds of pod are now available at dispensaries across the U.S.). If it looks just like the popular nicotine vape called the Juul, that’s because Pax Labs was spun off from the company that became Juul in 2017. 

Pax has been busy post-Juul. It brought on a new CEO, Bharat Vasan: steeped in Silicon Valley, Vasan was an executive at Electronic Arts, then co-founded a wearable device company that was bought by Intel for $100 million, then sold a smart lock and doorbell company before Pax came calling. The Era’s new microdosing ability comes via an update to its Bluetooth-linked app (iOS or Android) called Session Control. It marks Vasan’s first major impact on Pax’s direction.

The Pax Era’s new dosing options.

Image: pax

“Session Control make the vaping experience more predictable for people, especially those who are new to cannabis,” says Vasan. He and Jesse Silver, who is both Pax Labs’ VP of product and a prolific Burning Man artist, gave me an advance look at how it works. 

Up until now, the Pax app has allowed you to set the temperature of the vapor, allowing either for more subtle flavor or larger clouds from the Era. If that’s the horizontal axis (literally, on the app) Vasan and Silver see Session Control as the vertical axis controlling how much you get.

Turn the feature on and you have the options of micro, small, medium or large doses. A bar appears on the screen. Once you fill the bar with green by inhaling on the Pax Era, you’re done — or rather, you’re locked out of using the device for 30 seconds. 

Of course, you can just keep hitting the Pax again after 30 seconds if you want to defeat the purpose. (Or, if you’re not in the app, take the pod out and put it back in to disable Session Control.) But for those who are actively seeking moderation, or looking to eke out the contents of those expensive Pax Pods (which sell for anywhere between $30 and $100, depending on the strain), it’s an excellent constraint. 

The microdose is truly micro, and provides probably the most discreet, extremely low-level buzz you’ll ever feel. You could probably take a hit in the middle of a meeting and no one would notice. (Not that we’re recommending that.) 

How did Pax decide what a micro hit was? Technically, it’s all about the number of joules (not Juuls) of energy applied to the Pod by the Pax’s USB-chargeable battery. This is why you shouldn’t expect to see Session Control on Pax’s larger and more expensive vaporizer for cannabis flower, the $200 Pax 3; it’s harder to control the amount of energy provided to the Pax 3’s oven. That thing gets so hot, you can get high from it immediately after it’s turned off.  

But how did Pax decide how many joules were necessary? With the help of feedback from a large and enthusiastic beta testing community. This kind of feedback will determine where the company will go with Session Control technology in the future — possibly providing an “Extra Large” option, Vasan suggested, or an even more micro microdose. Or maybe allowing users with poor impulse control to change the amount of time they’re locked out of the device. 

Regardless, it’s an intriguing strategy that helps Pax in its goal to become what Vasan calls the iPhone of vaporizers: it just works, however you want it to work. Technically, encouraging people to use the product less (or in smaller doses) doesn’t affect Pax Labs’ bottom line, since the Pods are all filled by third parties. Pax just makes empty Pods and licenses their use.   

And if more people have a better, low level, more manageable experience while vaping weed, perhaps they’ll become long-term customers. And perhaps they’ll sample more Pax Pods now that they can effectively sip them. In this, as in so many other areas of consumption, less is more. 

Read more: http://mashable.com/

Mary JaneThe future of weed is microdosing. This company is ahead of the game
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John Boehner, who helped send drug dealers to prison, to lobby for marijuana

"My thinking/the profits on this matter have evolved."
Image: chip somodevilla/Getty Images

Now that he’s retired from Congress, former House Speaker John Boehner has decided to channel his inner flip-flopper and lobby for legalized weed. 

Boehner announced his decision Wednesday to join the board of Acreage Holdings, “an investment company with an established footprint in the cannabis industry in the United States.” 

“My thinking on cannabis has evolved,” Boehner said, sans winking emoji, in a tweet.

Boehner said he’d be lobbying to de-schedule the drug so we can “do research, help our veterans, and reverse the opioid epidemic ravaging our communities. research, help our veterans, and reverse the opioid epidemic.”

The former speaker’s decision comes at a time of soaring profits for the legalized cannabis industry, with $10 billion in sales recorded in 2017.

In 2011, John Boehner said he was “unalterably opposed to the legalization of marijuana or any other FDA Schedule I drug.” He added, “I remain concerned that legalization will result in increased abuse of all varieties of drugs, including alcohol.”

In fact, the former speaker spent much of his legislative career making life harder for drug users and instituting harsh penalties for drug sellers. In 1999, he voted to prohibit needle exchange and medical marijuana in D.C. — services that, arguably, help the the most vulnerable victims of the drug trade. In 2007, he voted against expanding services for ex-offenders leaving prison and re-entering public life. In 1999, he voted for a bill that allowed juveniles to be tried as adults for serious drug offenses.

Towards the end of his career in Congress, Boehner did signal an openness to getting people out of prison who “don’t really need to be there,” including non-violent drug offenders. The bill was never passed, and shortly thereafter, Boehner left Congress.

I wonder if Boehner’s thoughts on all of the drug bills he signed have also “evolved.”

My hunch is a giant “Nah.” 

Read more: http://mashable.com/

Mary JaneJohn Boehner, who helped send drug dealers to prison, to lobby for marijuana
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Why It’s So Hard to Dose Weed

Cannabis is a notoriously finicky drug. Take the right amount and you get relaxation or euphoria, but take too much and it’s a long ride of paranoia. Which makes marijuana tricky for casual users, and potentially problematic for new users who want to use cannabis to treat ailments like pain.

It's difficult to quantify just how much of the drug you’re inhaling through a bong or vaporizer—especially because marijuana contains some 500 chemicals that interact in ways scientists are just beginning to understand. And really, how you end up feeling depends as much on your physiology and state of mind as it does on the plant.

But, some good news. For one, science only has more to learn about how marijuana works on the human body. And two, companies making cannabis devices are figuring out ways to tackle the dosing problem.

Take the Resolve One smart inhaler (formerly known as Breeze) for medical marijuana users who also happen to be data nerds, coming out in May. Think of it like the Keurig of cannabis: Insert a “Smart Pod” of marijuana and the device administers a precise blast of vapor. The device pairs with a smartphone app, where users begin by inputting their pain level. The inhaler calculates the right dose, followed by a drag. Ten minutes later, once the cannabis has kicked in, the app pings them to rate their pain again. This helps the user determine how effective the dose was.

And it helps Resolve One's maker, Resolve Digital Health, do the same: By gathering more and more data, it can build pain profiles. Some folks wake up in pain, for instance, while for others the pain builds throughout the day. So how might cannabis help mitigate these different experiences? How might the drug interact with other medications the person is taking? (Users are encouraged to log these in the Resolve One app.) How do other medical conditions factor into the pain problem? (You log these too.)

Resolve’s goal is to use data from Resolve One to help not only individual users, but to build a better understanding of how cannabis can treat pain. “I think patients of the future, and we're seeing it right now with cannabis patients, are data-empowered patients,” says Rob Adelson, president and CEO of Resolve. “They want information, they want to collect it, they want to share it, they want to compare it.”

Now, it’s clear that accumulating more and more data hasn’t cured cancer or helped humans figure out how to stop aging. But in the case of cannabis, scientists have so little detailed information about user responses that it makes sense to start looking. Especially because the effects of cannabis can vary wildly from user to user. Some people, for instance, can handle higher THC content than others without having a conniption. And how marijuana affects you can even vary based on how much food you’ve had that day, especially if you’re consuming edibles.

“It's going to take a long time for us to get to the level of knowledge that we all need to be at to understand how this plant works, specifically for very specific health conditions,” says Adelson. “But what we'll do is collect that data, and then put some of those insights and findings into clinical studies where we can go deeper into it.”

dosist

The uncertainty is especially challenging given how potent cannabis has become. One study found that THC levels have gone up three-fold since 1995, thanks to selective breeding. But patients may be more interested in high levels of CBD, the non-psychoactive component that could help treat ailments like epilepsy.

“Our focus is on mitigating the intoxicating effects of cannabis, which is a very different mindset than a lot of cannabis brands,” says Gunner Winston, CEO of Dosist, which makes dose pens. “A lot of people don't want to be intoxicated.”

The trick may be something called the entourage effect, the idea that the plant’s various compounds interact with one another to put a check on the psychoactive effects on THC. Specifically, you’d want a lot of CBD in there. Yet science hasn’t proved out this effect.

“I think the anecdotal mountain of evidence says that it does exist,” says Jeff Raber, CEO of the Werc Shop, a lab that tests cannabis. “But we don't know why or how or which ones are doing what.”

And that’s just when it comes to ingesting and inhaling cannabis. “We actually know very little about other modes of administration,” says UC San Diego researcher Igor Grant, who studies cannabis. “People talk about having skin patches and various kinds of gels. The work just hasn't been done to show whether that actually delivers the cannabis in the way that you would want in an effective dose.”

But as far as inhaled marijuana is concerned, companies like Resolve Digital Health and Dosist are starting to tackle the quantification problem, the former catering to patients and the later to a more general audience. And they’re betting that demand for a more predictable cannabis experience is only going up.

“People are asking for this,” says Winston of Dosist. “We can debate all day how much science has been done and should be done, but when you look across the country people are demanding cannabis for therapeutic purposes.”

Remember: Until there’s a fool-proof system for accurately dosing inhaled cannabis—and there may never will be—go low and slow. Your brain will thank you.

Read more: http://www.wired.com/

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Lawyer Promised Their Weed Was Legal, But It Landed Them in Jail

Marsha Yandell was getting ready for lunch when a SWAT team appeared on her lawn and shouted over a bullhorn to smoke her out.

It was February 2015, and the former registered nurse tried to tell Florida cops that she had paperwork for her cannabis plants. The documents, she claimed, showed she and her hubby Scott were allowed to grow medical marijuana.

Yandell was tackled and zip-tied once she emerged, while her husband phoned their attorney from inside the house. The lawyer, Ian James Christensen, had legally greenlighted their home-grow operation and provided them with a patient ID card.

Scott, then an engineer, was cuffed and charged, too. The couple faced a slew of felonies, including manufacturing cannabis and possession of cannabis with intent to sell or deliver, and decades behind bars.

The Yandells lost their home and their jobs. They took a plea deal in return for $15,000 in fines, three years of probation, and 100 hours of community service, court records show.

Nine months after their arrests, Christensen closed his law firm. He eventually left Florida and faces a federal lawsuit by the Yandells accusing him of legal malpractice. (A default judgment against Christensen was entered this month.)

Last week, the 30-year-old one-time barrister was disbarred for falsely telling his sick clients they could possess, use, and grow cannabis. Christensen claimed cops couldnt touch them as long as they had his Official Legal Certification and (phony) patient ID cards. At the time, medical marijuana wasnt even legal in the Sunshine State.

Two other peoplean Iraq War contractor with PTSD and his girlfriendwere arrested and prosecuted after following Christensens advice, a state bar investigation found.

Along with the Official Legal Certification, Christensen provided clients with grow signs they could post at their homes to announce they were cultivating medical marijuana, a Florida Supreme Court ruling stated.

In a Jan. 18 decision, the court ruled that Christensen erroneously advised his clients and gave them legally meaningless certifications based on determinations made by a physician not licensed to practice medicine in the State of Florida.

Christensen continued to insist on the correctness of his clearly erroneous legal positions even when facing disciplinary proceedings, the document states.

We will not tolerate such misconduct by members of The Florida Bar, the panel wrote in their decision.

Christensens attorney, D. Gray Thomas, released a statement suggesting his client never intended to harm anyone.

A young lawyer thought at the time that he was serving his clients rights and best interests, and was advising them appropriately, Thomas said. He thought he was raising a valid position on their behalf supported by existing Florida legal precedent on the defense of medical necessity.

In court papers, Thomas wrote that Christensen opened his own solo firm, unmonitored by an experienced law firm or attorney.

Christensen, in an affidavit, said, …I am extremely remorseful for the harms caused to my clients based on my naive persistence and misplaced confidence in what I was doing harms which I did not intend.

But Andrew Bonderud, an attorney for the Yandells, called Christensen a scam artist.

He has demonstrated a level of intransigence and arrogance that is remarkable, Bonderud told The Daily Beast. He had lots of opportunities to be persuaded that what he was recommending was hazarding all of his clients, and he ignored them.

Its a level of recklessness that cannot be explained away by an innocent misunderstanding, Bonderud added.

While Marsha Yandell is happy with the disbarment, she says her life is still in pieces. She and her spouse moved to Oregon for a fresh start, but her criminal record bars her from being employed as a nurse. I dont want this to ever happen to another vulnerable patient, ever again, she told The Daily Beast.

Yandell was a registered nurse for 25 years and lost her license after pleading guilty to possession of cannabis with intent to sell and possession of paraphernalia. Her husband, an engineer for 15 years, also lost his job at Verizon, she says.

Were very educated people, however, we are not educated in law, Yandell said.

Before she found Christensens firm, Yandell was suffering from fibromyalgia, anxiety, depression, and spinal stenosis. Desperate to ditch the daily pharmaceuticals she took to ease the pain, she attended a cannabis seminar and learned of Christensens business, Health Law Services (HLS).

Indeed, Christensen launched the IJC Law Group in July 2013, less than three months after being admitted to the bar. At the time, he had no training in the area of medical marijuana, the Florida Supreme Court found.

The attorney launched HLS in February 2014, and incorporated the Cannabinoid Therapy Institute five months later, court papers state.

Christensen charged HLS clients $799 a pop for a medical necessity evaluation. If his firm determined a need for weed, it would provide patients with the Official Legal Certification and a homemade ID card claiming the clients had a marijuana prescription.

The identification was not affiliated with any government agency.

HLS website erroneously claimed Floridas medical necessity doctrine would protect patients from law enforcement if they could prove they used pot for medical reasons. Therefore, if a patient can prove to a law enforcement officer that cannabis is the safest medication available to treat their diagnosed condition, they are NOT subject to arrest, the website stated.

Meanwhile, Christensens Facebook page boasted of being the first law firm to develop a process to assist you TODAY so you may rest easy knowing you have a valid legal option to use this safe non-toxic medicine.

He claimed to have a team of expert physicians, attorneys, and experienced marijuana professionals. Yet, according to the Yandells lawsuit, one of those experts claimed to be a lawyer but didnt even have a bachelors degree.

The Yandells met Christensen in June 2014 and paid him $799 each after they received a medical interview by a doctor, whom they later learned wasnt even licensed to practice in the state of Florida.

At the time, Marsha Yandell was desperate for a cure.

I was eating 15 pills a day with every doctor in Jacksonville saying, Im sorry youre feeling so bad, but theres not a lot I can do, Yandell said.

When I met these people, and they told me they had a way out of that whole rat race that I was living I was like, Hell yeah, I will try anything, Yandell recalls. If somebody would have told me to scrape asphalt off the left side of the highway and eat it, I would have done that.

The couple later showed Christensen their home cannabis plants, and the budding attorney allegedly restated that the operation was legal.

Christensen found ways to add validity to his practice by creating a website where law enforcement could search for and confirm whether patient ID cards were valid, Yandell told The Daily Beast.

She and her husband continued to cultivate marijuana until January 2015, when a former friend and HLS patient made a false 911 call about them, the lawsuit states. (Yandell said the pal was angry when she stopped growing his medicine for free. He allegedly told police he heard gunshots at the Yandell residence.)

According to the lawsuit, Christensen told the Yandells they had nothing to worry about and that his firm would contact the Saint Johns County Sheriffs Office to discuss the couples marijuana operation. There is no record, however, that Christensen ever contacted the agency.

One month later, the SWAT team raided their home and seized their vehicles and other valuables.

The Yandells paid HLS $3,000 in cash, in addition to filing fees, to have Christensen represent them after their first arrest.

When cops busted the couple a second time in March 2015, they hired a new attorney. They pleaded guilty to avoid lengthy prison sentences, becoming homeless, broke, convicted felons, their complaint states.

Their landlord later won a $25,000 judgment against them for lost rent and damages to the home from the police raid.

The Yandells werent the only victims of Christensens alleged scheme, court papers filed in the disbarment case reveal.

In June 2014, Matthew Young and his girlfriend, Lynne Nesselroad, sought advice on Floridas medical marijuana laws.

Christensen sent Young to his Cannabinoid Therapy Institute for an exam. Afterward, Christensen told Young he could grow and use weed for his medical conditions which include PTSD and brain injury.

Three months later, Christensen provided Young with a patient ID card and Nesselroad with a card identifying her as his qualified caregiver. Christensen was listed on both ID cards as their Licensed Florida Counsel.

In November 2014, Young and Nesselroad were arrested for trafficking marijuana and possession and manufacture of cannabis. Cops laughed when Young showed them Christensens paperwork, court papers state.

Christensen charged the couple $8,000 to defend them, but a judge disqualified him as their attorney because he was a witness in the case. When Young and Nesselroad tried to get a refund, Christensen allegedly told them the money was gone.

The State Attorneys Office dropped all charges against the couple in July 2015, and they became cooperating witnesses in an ongoing investigation, the Tampa Bay Times reported. That month, a judge also ordered Christensen to repay the $8,000.

Young had spent 1,600 days in Iraq as a military contractor. His tour left him with broken bones, PTSD, and brain injury from concussions he sustained during explosions. His attorney, Shawn Gearhart, told the Times that he also contracted HIV while working as a field medic and was later diagnosed with AIDS.

It calms everything, Young told the Times. Without cannabis my head is like a tornado and a hurricane all at the same time.

According to the Times, state attorney Bruce Bartlett said that without Christensens guidance, Young and Nesselroad wouldnt have faced their predicament. These people have been punished enough, Bartlett said.

Read more: http://www.thedailybeast.com

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John Boehner, who helped send drug dealers to prison, to lobby for marijuana

"My thinking/the profits on this matter have evolved."
Image: chip somodevilla/Getty Images

Now that he’s retired from Congress, former House Speaker John Boehner has decided to channel his inner flip-flopper and lobby for legalized weed. 

Boehner announced his decision Wednesday to join the board of Acreage Holdings, “an investment company with an established footprint in the cannabis industry in the United States.” 

“My thinking on cannabis has evolved,” Boehner said, sans winking emoji, in a tweet.

Boehner said he’d be lobbying to de-schedule the drug so we can “do research, help our veterans, and reverse the opioid epidemic ravaging our communities. research, help our veterans, and reverse the opioid epidemic.”

The former speaker’s decision comes at a time of soaring profits for the legalized cannabis industry, with $10 billion in sales recorded in 2017.

In 2011, John Boehner said he was “unalterably opposed to the legalization of marijuana or any other FDA Schedule I drug.” He added, “I remain concerned that legalization will result in increased abuse of all varieties of drugs, including alcohol.”

In fact, the former speaker spent much of his legislative career making life harder for drug users and instituting harsh penalties for drug sellers. In 1999, he voted to prohibit needle exchange and medical marijuana in D.C. — services that, arguably, help the the most vulnerable victims of the drug trade. In 2007, he voted against expanding services for ex-offenders leaving prison and re-entering public life. In 1999, he voted for a bill that allowed juveniles to be tried as adults for serious drug offenses.

Towards the end of his career in Congress, Boehner did signal an openness to getting people out of prison who “don’t really need to be there,” including non-violent drug offenders. The bill was never passed, and shortly thereafter, Boehner left Congress.

I wonder if Boehner’s thoughts on all of the drug bills he signed have also “evolved.”

My hunch is a giant “Nah.” 

Read more: http://mashable.com/

Mary JaneJohn Boehner, who helped send drug dealers to prison, to lobby for marijuana
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California weed stored serves 23,606 people in first month

Image: medmen

The first month of California’s legal recreational marijuana sales showed that weed is big business, despite local government’s reluctance to issue permits.

MedMen, a cannabis company that’s basically an Apple Store for pot products has dispensaries across Los Angeles, and found itself in an interesting position as one of the few places people could purchase marijuana in the most densely populated areas of Los Angeles when legalized sales began in California.

At MedMen’s West Hollywood location, customer traffic clocked in a 23,606 people in January alone. Revenue was up 200 percent, compared to December, and up 500 percent compared to the year before. Its Santa Ana location brought in 5,051 people, doubling December’s revenue. 

MedMen’s West Hollywood location.

Image: medMen

Since recreational pot sales began on Jan. 1, Californians have been flocking to the few dispensaries that are allowed to sell to residents without medical cards. Proposition 64, which legalized recreational cannabis, lets local governments regulate sales. 

Some cities in Los Angeles county have been resistant to recreational weed. Santa Monica, for example, has banned non-medical marijuana storefronts entirely. Long Beach issued a 180 day ban on recreational sales at the end of 2017, giving the city time to figure out regulations. 

The city of Los Angeles set up framework for regulation, but businesses couldn’t apply for licenses until January 3. Vendors also had to apply for a separate license from the state-run Bureau of Cannabis Control.

The city of West Hollywood issued temporary permits for stores like MedMen. The California Bureau of Cannabis Cannabis Control issued only 47 temporary retail licenses, but they’ll expire by May 1. 

The unique position helped set up MedMen to be a marijuana unicorn. Canadian investment firm Captor Capital invested $30 million in the company for just 3 percent, valuing the company at about $1 billion.

Read more: http://mashable.com/

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Girl Scout sells 300 boxes of cookies outside a California dispensary

Image: Getty Images

This Girl Scout knows her customers well. 

The young entrepreneur set up shop outside of Urbn Leaf, a recreational and medical marijuana dispensary in San Diego. According to local news outlet Fox 4, the girl sold more than 300 boxes in about six hours. 

Urbn Leaf posted this photo on Instagram, encouraging its clientele to grab some “Girl Scout Cookies with your GSC.” (GSC is a strain of weed named after girl scout cookies, and is known for its “sweet and earthy” flavor.)

A post shared by Urbn Leaf (@urbnleafca) on

“I think our customers loved it,” said Savannah Rakofsky, a representative for Urbn Leaf. “They went out and bought boxes.” 

According to Rakofsky, there was an “added value” to visiting the dispensary and getting the chance to buy Girl Scout cookies. Although it didn’t necessarily bring in customers, it did drum up publicity for Urbn Leaf. Rakofsky posted the photo as she was leaving for her lunch break, and there were already news teams at the store when she came back.

Rakofsky also said there’s a possibility of this becoming a trend. 

“The funny thing is, after the news story ran, we had more Girl Scouts show up over the weekend,” Rakofsky said. 

Although Girl Scouts are only allowed to sell at “approved sites” — which doesn’t include pot shops — this particular scout got around the rule by selling cookies from her wagon, and by moving up and down the sidewalk instead of staying in front of the store. Alison Bushan, a spokeswoman for Girl Scouts San Diego, told the San Diego Union-Tribune that this tactic was “gray area.”

It wouldn’t be the first time a Girl Scout racked in sales in front of a dispensary. In 2014, one savvy scout sold cookies outside of a San Francisco cannabis clinic. Girl Scouts of Northern California actually condoned it, because “the mom decided this was a place she was comfortable with her daughter being at.”

Rakofsky said Urbn Leaf would be “totally open to” allowing Girl Scouts to sell cookies outside their storefronts regularly, if the organization allowed it. “We have no problem,” she said. “But unfortunately that’s not us, that’s the Girl Scouts.” 

WATCH: ‘French Spider-Man’ casually climbs Paris skyscraper in epic feat

Read more: http://mashable.com/

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The Dirty Secret of California’s Cannabis: It’s Dirty

This is a story about marijuana that begins in a drawer of dead birds. In the specimen collections of the California Academy of Sciences, curator Jack Dumbacher picks up a barred owl—so named for the stripes than run across its chest—and strokes its feathers. It looks like a healthy enough bird, sure, but something nefarious once lurked in its liver: anticoagulant rodenticide, which causes rats to bleed out, and inevitably accumulates in apex predators like owls. The origin of the poison? Likely an illegal cannabis grow operation in the wilds of Northern California.

Wired

“It's a mess out there,” says Dumbacher. “And it costs taxpayers millions of dollars to clean up the sites.”

Marijuana doesn’t just suddenly appear on the shelves of a dispensary, or the pocket of a dealer. Someone’s gotta grow it, and in Northern California, that often means rogue farmers squatting on public lands, tainting the ecosystem with pesticides and other chemicals, then harvesting their goods and leaving behind what is essentially a mini superfund site. Plenty of growers run legit, organic operations—but cannabis can be a dirty, dirty game.

Morgan Heim/BioGraphic/California Academy of Sciences
Morgan Heim/BioGraphic/California Academy of Sciences

As cannabis use goes recreational in California, producers are facing a reckoning: They’ll either have to clean up their act, or get out of the legal market. Until the federal prohibition on marijuana ends, growers here can skip the legit marketplace and ship to black markets in the many states where the drug is still illegal. That’s bad news for public health, and even worse news for the wildlife of California.

If you’re buying cannabis in the United States, there’s up to a 75 percent chance that it grew somewhere in California. In Humboldt County alone, as many as 15,000 private grows churn out marijuana. Of those 15,000 farms, 2,300 have applied for permits, and of those just 91 actually have the permits.

Researchers reckon that 15 to 20 percent of private grows here are using rodenticide, trying to avoid damage from rats chewing through irrigation lines and plants. Worse, though, are the growers who hike into rugged public lands and set up grow operations. Virtually all of them are using rodenticide. “At very high doses the rodenticides is meant to kill by basically stopping coagulation of blood,” says Dumbacher. “So what happens is if you get a bruise or a cut it you would you would literally bleed out because it won’t coagulate.”

And what’s bad for the rats can’t be good for the barred owl. How the poison might affect these predators isn’t immediately clear, but researchers think it may weaken them.

Scientists are used to seeing rodenticides in owl livers—but usually, those animals are picking off rats in urban areas. Not so for these samples. “When we actually looked at the data, it turned out that some of the owls that were exposed were from remote areas parts of the forest that don't have even roads near them,” says Dumbacher. When researchers took a look at satellite images of these areas, they were able to pick out illegal grow operations and make the connection: Rodenticides from marijuana cultivation are probably moving up the food chain.

The havoc that growers are wreaking in Northern California is worryingly similar to the environmental bedlam of the past. “We can't just take exactly the same historical approach that California did with the Gold Rush,” says Mourad Gabriel, executive director of the Integral Ecology Research Center and lead author of the study with Dumbacher. It was a massive inundation of illegal gold and mining operations that tore the landscape to pieces. “150 years down the road, we are still dealing with it.”

And Northern California’s problems have the potential to become your problem if you’re buying marijuana in a state where it’s still illegal. “We have data clearly demonstrating the plant material is contaminated, not just with one or two but a plethora of different types of pesticides that should not be used on any consumable product,” says Gabriel. “And we find it on levels that are potentially a threat to humans as well.”

Lab Rats

Across from an old cookie factory in Oakland, California sits a lab that couldn’t look more nondescript. It’s called CW Analytical, and it’s in the business of testing marijuana for a range of nasties, both natural and synthetic. Technicians in lab coats shuffle about, dissolving cannabis in solution, while in a little room up front a man behind a desk consults clients.

Morgan Heim/BioGraphic/California Academy of Sciences

Running this place is a goateed Alabama native named Robert Martin. For a decade he’s risked the ire of the feds to ensure that the medical marijuana sold in California dispensaries is clean and safe. But in the age of recreational cannabis, the state has given him a new list of enemies to test for. If you're worried about consuming grow chemicals like the owls are doing, it's scientists like Martin who have your back.

“We're trying to do it in legitimate ways, not painting our face or putting flowers in our hair,” says Martin. “We're here to show another face of the industry." Clinical. Empirical.

Labs like these—the Association of Commercial Cannabis Laboratories, which Martin heads, counts two dozen members—are where marijuana comes to pass the test or face destruction. Martin’s team is looking for two main things: microbiological contaminants and chemical residues. “Microbiological contaminants could come in the form of bacteria or fungi, depending on what kind of situation your cannabis has seen,” says Martin. (Bad drying or curing habits on the part of the growers can lead to the growth of Aspergillus mold, for instance.) “Or on the other side, the chemical residues can be pesticides, herbicides, things like that.”

The biological bit is pretty straightforward. Technicians add a cannabis sample to solution, then spread it on plates that go into incubators. “What we find is of all the flowers that come through, about 12 to 13 percent will come back with a high level of aerobic bacteria and about 13 to 14 percent will come back with a high level of fungi and yeast and mold,” says laboratory manager Emily Savage.

With chemical contaminants it gets a bit trickier. To test for these, the lab run the cannabis through a machine called a mass spectrometer, which isolates the component parts of the sample. This catches common chemicals like myclobutanil, which growers use to kill fungi.

Starting July 1 of this year, distributors and (legal) cultivators have to put their product through testing for heavy metals and bacteria like E. coli and chemicals like acephate (a general use insecticide). That’s important for average consumers but especially medical marijuana patients with compromised health. One group of researchers has even warned that smoking or vaping tainted marijuana could lead to fatal infections for some patients, as pathogens are taken deep into the lungs.

“This is why we have to end prohibition and regulate and legalize cannabis, so that we can develop the standards that everybody must meet,” says Andrew DeAngelo, director of operations of the Harborside dispensary in Oakland.

After testing, a lab like CW has to report their results to the state, whose guidelines may dictate that the crop be destroyed. If everything checks out, the marijuana is cleared for sale in a dispensary. “That gives the public confidence that these supply chains are clean for them and healthy for them,” says DeAngelo.

That safety comes at a price, though. To fund the oversight of recreational marijuana, California is imposing combined taxes of perhaps 50 percent. “They're too high,” says DeAngelo. He’s worried that the fees will push users back into the black market, where plants don’t have to hew to the same strict safety standards. “This shop should be a lot fuller than it is right now.”

And the black market gets us right back to the mess we started off in. Illegal cultivation is bad for consumers and bad for the environment. The only real solution? The end of prohibition. At the very least, the owls would appreciate it.

Read more: http://www.wired.com/

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Why No Gadget Can Prove How Stoned You Are

If you’ve spent time with marijuana—any time at all, really—you know that the high can be rather unpredictable. It depends on the strain, its level of THC and hundreds of other compounds, and the interaction between all these elements. Oh, and how much you ate that day. And how you took the cannabis. And the position of the North Star at the moment of ingestion.

OK, maybe not that last one. But as medical and recreational marijuana use spreads across the United States, how on Earth can law enforcement tell if someone they’ve pulled over is too high to be driving, given all these factors? Marijuana is such a confounding drug that scientists and law enforcement are struggling to create an objective standard for marijuana intoxication. (Also, I’ll say this early and only once: For the love of Pete, do not under any circumstances drive stoned.)

Sure, the cops can take you back to the station and draw a blood sample and determine exactly how much THC is in your system. “It's not a problem of accurately measuring it,” says Marilyn Huestis, coauthor of a new review paper in Trends in Molecular Medicine about cannabis intoxication. “We can accurately measure cannabinoids in blood and urine and sweat and oral fluid. It's interpretation that is the more difficult problem.”

You see, different people handle marijuana differently. It depends on your genetics, for one. And how often you consume cannabis, because if you take it enough, you can develop a tolerance to it. A dose of cannabis that may knock amateurs on their butts could have zero effect on seasoned users—patients who use marijuana consistently to treat pain, for instance.

The issue is that THC—what’s thought to be the primary psychoactive compound in marijuana—interacts with the human body in a fundamentally different way than alcohol. “Alcohol is a water-loving, hydrophilic compound,” says Huestis, who sits on the advisory board for Cannabix, a company developing a THC breathalyzer.1 “Whereas THC is a very fat-loving compound. It's a hydrophobic compound. It goes and stays in the tissues.” The molecule can linger for up to a month, while alcohol clears out right quick.

But while THC may hang around in tissues, it starts diminishing in the blood quickly—really quickly. “It's 74 percent in the first 30 minutes, and 90 percent by 1.4 hours,” says Huestis. “And the reason that's important is because in the US, the average time to get blood drawn [after arrest] is between 1.4 and 4 hours.” By the time you get to the station to get your blood taken, there may not be much THC left to find. (THC tends to linger longer in the brain because it’s fatty in there. That’s why the effects of marijuana can last longer than THC is detectable in breath or blood.)

So law enforcement can measure THC, sure enough, but not always immediately. And they’re fully aware that marijuana intoxication is an entirely different beast than drunk driving. “How a drug affects someone might depend on the person, how they used the drug, the type of drug (e.g., for cannabis, you can have varying levels of THC between different products), and how often they use the drug,” California Highway Patrol spokesperson Mike Martis writes in an email to WIRED.

Accordingly, in California, where recreational marijuana just became legal, the CHP relies on other observable measurements of intoxication. If an officer does field sobriety tests like the classic walk-and-turn maneuver, and suspects someone may be under the influence of drugs, they can request a specialist called a drug recognition evaluator. The DRE administers additional field sobriety tests—analyzing the suspect’s eyes and blood pressure to try to figure out what drug may be in play.

The CHP says it’s also evaluating the use of oral fluid screening gadgets to assist in these drug investigations. (Which devices exactly, the CHP declines to say.) “However, we want to ensure any technology we use is reliable and accurate before using it out in the field and as evidence in a criminal proceeding,” says Martis.

Another option would be to test a suspect’s breath with a breathalyzer for THC, which startups like Hound Labs are chasing. While THC sticks around in tissues, it’s no longer present in your breath after about two or three hours. So if a breathalyzer picks up THC, that would suggest the stuff isn’t lingering from a joint smoked last night, but one smoked before the driver got in a car.

This could be an objective measurement of the presence of THC, but not much more. “We are not measuring impairment, and I want to be really clear about that,” says Mike Lynn, CEO of Hound Labs. “Our breathalyzer is going to provide objective data that potentially confirms what the officer already thinks.” That is, if the driver was doing 25 in a 40 zone and they blow positive for THC, evidence points to them being stoned.

But you might argue that even using THC to confirm inebriation goes too far. The root of the problem isn’t really about measuring THC, it’s about understanding the galaxy of active compounds in cannabis and their effects on the human body. “If you want to gauge intoxication, pull the driver out and have him drive a simulator on an iPad,” says Kevin McKernan, chief scientific officer at Medicinal Genomics, which does genetic testing of cannabis. “That'll tell ya. The chemistry is too fraught with problems in terms of people's individual genetics and their tolerance levels.”

Scientists are just beginning to understand the dozens of other compounds in cannabis. CBD, for instance, may dampen the psychoactive effects of THC. So what happens if you get dragged into court after testing positive for THC, but the marijuana you consumed was also a high-CBD strain?

“It significantly compounds your argument in court with that one,” says Jeff Raber, CEO of the Werc Shop, a cannabis lab. “I saw this much THC, you're intoxicated. Really, well I also had twice as much CBD, doesn't that cancel it out? I don't know, when did you take that CBD? Did you take it afterwards, did you take it before?

“If you go through all this effort and spend all the time and money and drag people through court and spend taxpayer dollars, we shouldn't be in there with tons of question marks,” Raber says.

But maybe one day marijuana roadside testing won’t really matter. “I really think we're probably going to see automated cars before we're going to see this problem solved in a scientific sense,” says Raber. Don’t hold your breath, then, for a magical device that tells you you’re stoned.

1 UPDATE: 1/29/18, 2:15 pm ET: This story has been updated to disclose Huestis' affiliation with Cannabix.

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